In 1890, German medical professor Wilhelm Erb and other physicians had been observing several cases of a neuromuscular disease that they believed was affecting how nerve impulses were transmitted to muscle at the neuromuscular junction. The patient’s experienced a ‘grave muscular weakness’ and Wilhelm named it myasthenia graves. Through further research, the physicians discovered whether it affected the eye muscles first, or created difficulty in talking, chewing and swallowing, or in using the arms and legs it was neither hereditary nor contagious. Their discoveries lead to more detailed research.
In the early 1970 s when Muscular Dystrophy Association, using snake venom, observed that patients with the disease had decreased numbers of acetylcholine receptors. Thus, discovering that the disease affected acetylcholine receptors of the skeletal muscles. The Muscular Dystrophy Association also found that, in rabbits, an immune attack against the acetylcholine receptors resulted in muscle membrane damage that is similar to that seen in human myasthenia graves. This rabbit experiment was responsible for a large portion of what scientists now know about myasthenia graves. Myasthenia graves causes a progressive and abnormally rapid fatigue of the voluntary muscles. It is known as an autoimmune disease, in which the body generates an immune system attack against its own skeletal muscles.
This arises when lymphocytes in the blood produce antibodies that destroy muscle-cell receptors for acetylcholine molecules, preventing muscle contractions. The antibodies have been shown to decrease the usefulness of acetylcholine receptors through accelerated and blockade of the receptor. Endocytosis is when extracellular substances are being incorporated into the cell by vesicles forming inward through budding of the plasma membrane. Researchers have been able to demonstrate the effect of antibodies on acetylcholine receptor by using radioactively labeled alpha toxin, a snake poison, to follow the rate of degradation. Antibodies from patients with myasthenia graves cause an increase in the rate of degradation of acetylcholine receptors.
The Essay on Differences Between the Excitation-Contraction Coupling Mechanism Between Skeletal and Cardiac Muscles
Outline the differences between the excitation-contraction coupling mechanism between skeletal and cardiac muscles. Excitation-contraction coupling is the combination of the electrical and mechanical events in the muscle fibres and is related by the release of calcium from the sarcoplasmic reticulum. (Silverthorn, 2007) In the skeletal muscle, action potential in the nerves is generated when the ...
Blockade of acetylcholine receptors is another form of autoimmune attack from myasthenia graves. Antibodies from these patients have been shown to block the acetylcholine binding sites preventing acetylcholine from binding to its receptor and opening the ion channel. The antibodies may bind near the acetylcholine binding site rather than directly on it, because the acetylcholine binding site is so small. In this case, the antibodies would prevent acetylcholine from binding at the receptor by interfering with the acetylcholine molecule as it moves towards its receptor. Symptoms for some one with myasthenia graves include a flattened smile and droopy eyes, with slow pupillary light responses. The person with myasthenia graves, myasthenic patient, may have fixed column deformity or irregular posture after standing for a short time period.
Nasal speech, difficulty chewing and swallowing, dulled facial expression, including difficulty smiling and an ineffective cough due to weak expiratory muscles, are all also frequently associated with myasthenia graves. The degree of muscle weakness involved in myasthenia graves varies greatly among patients. However, the myasthenic patient has no loss of reflexes or alteration of sensation or coordination and generally doesn’t complain about feelings of fatigue. Instead, they experience localized fatigue in specific, repeatedly used muscle groups.
The Essay on Amino Acid Sites Receptor Binding
The tethered agonist approach to mapping ion channel proteins - toward a structural model for the agonist binding site of the acetylcholine receptor. Research by Linton g Li, We nge Zhong, Niki Zacharias, Caroline Gibbs, Henry A Lester, Dennis A. Dougherty. Condensation of the Research Purpose of the Study: The purpose of the study was to develop a structural model for the acetylcholine receptor ...
Who gets myasthenia graves? Myasthenia graves occurs in all ethnic groups and both genders. It most commonly affects young adult women, under 40, and older men, over 60, but it can occur at any age. Studies showed that women were often affected more than men were. Now, males are more often affected than females, and the onset of symptoms is usually after age 50. In birth development stages, the fetus may acquire antibodies from a mother affected with myasthenia graves. Generally, cases of neonatal myasthenia graves are temporary and the child’s symptoms usually disappear within a few weeks after birth.
Other children develop myasthenia graves indistinguishable from that seen in adults. Myasthenia graves in juveniles is common. As Professor Wilhelm Erb discovered myasthenia graves is not directly inherited nor is it contagious. Occasionally, the disease may occur in more than one member of the same family. Children rarely develop myasthenia graves; instead, they may show signs of congenital myasthenia or congenital myasthenic syndrome. These are not autoimmune disorders, but are caused by defective genes that control proteins in the acetylcholine receptor or in.
More and more research is conducted everyday in search of a cure for myasthenia graves. One main contributor to the awareness of this disease is the Myasthenia Gravis Foundation of America. It is a national volunteer health agency dedicated solely to the fight against myasthenia graves. As technology increases, hopefully some one will find a cure.
