Oxidative Stress in Women with Polycystic Ovary Syndrome
OBJECTIVE: To determine if oxidative stress and endothelial dysfunction exist at the same time in a young, non-obese group of patients with polycystic ovary syndrome (PCOS).
DESIGN: Cross-sectional study.
SAMPLE: Thirty-one young, non-obese patients with PCOS and 23 age- and body mass index-matched controls.
METHODS: Following clinical and biochemical diagnosis, malonyldialdehyde (MDA), superoxide dismutase (SOD), von Willebrand Factor (vWF), and nitric oxide (NO) levels of patients and controls were measured and compared.
MAIN OUTCOME MEASURES: To find out oxidative stress and endothelial dysfunction parameters.
RESULTS: MDA (0.12+/-0.03 vs 0.10+/-0.03, p=0.01) and SOD (8.0+/-0.7 vs 7.28+/-0.8, p=0.001) levels were significantly higher in PCOS group while there was no difference in vWF (527.2+/-280.1 vs 568.1+/-276.8, p>0.05) and NO levels (169.9+/-47.4 vs 168.9+/-80, p>0.05).
When the results of the PCOS patients were divided into two subgroups in terms of insulin resistance (IR- and IR + ), the IR- subgroup had significantly higher MDA levels compared to the control (0.125+/-0.03 vs 0.101+/-0.03, p=0.03).
Though IR+ group also had higher MDA than the control group, it did not reach to a significant level (0.117+/-0.05 vs 0.101+/-0.03, p>0.05).
Both IR- and IR+ groups had significantly higher SOD levels compared with control group (7.99+/-0.7 vs 7.28+/-0.8, p=0.009 and 8.22+/-0.8 vs 7.28+/-0.8, p=0.03, respectively).
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vWF and NO levels were not different among these three groups (p>0.05).
CONCLUSIONS: Oxidative stress is prominent while endothelial dysfunction does not exist in young, non-obese patients with PCOS.
OBJECTIVE: To investigate the correlation between oxidative stress and PCOS, to provide an evidence for the treatment of PCOS
METHODS: The levels of maternal serum LPO, MDA, SOD, VE and VC were measured in 30 patients with PCOS (PCOS group 1) and in 30 normal women (control group) by chemicalorimetry. After being measured, the patients with PCOS (PCOS group 1) took VE 0.1 qd x 3 months, VC 0.2 bid x 3 months and Diane-35 (Ethinylestradiol and Cyproterone Acetate Tablets) 1 # qd x 21 d/month x 3 months. The LPO, MDA, SOD, VE and VC were measured after three months. The other 30 patients with PCOS (PCOS group 2) were chosen to take Diane-35 (Ethinylestradiol and Cyproterone Acetate Tablets) 1 qd x 21 d/month x 3 months only. The menstrual cycles were viewed in PCOS group 1 and PCOS group 2 for three months
.
Main outcome measure(s)
C-reactive protein (CRP), lipid fractions, glucose, protein carbonyls, insulin, and other hormone (gonadotropins, androgens) levels
METHODS: Following clinical and biochemical diagnosis, malonyldialdehyde (MDA), superoxide dismutase (SOD), von Willebrand Factor (vWF), and nitric oxide (NO) levels of patients and controls were measured and compared.
MAIN OUTCOME MEASURES: To find out oxidative stress and endothelial dysfunction parameters.
RESULTS: MDA (0.12+/-0.03 vs 0.10+/-0.03, p=0.01) and SOD (8.0+/-0.7 vs 7.28+/-0.8, p=0.001) levels were significantly higher in PCOS group while there was no difference in vWF (527.2+/-280.1 vs 568.1+/-276.8, p>0.05) and NO levels (169.9+/-47.4 vs 168.9+/-80, p>0.05).
When the results of the PCOS patients were divided into two subgroups in terms of insulin resistance (IR- and IR + ), the IR- subgroup had significantly higher MDA levels compared to the control (0.125+/-0.03 vs 0.101+/-0.03, p=0.03).
Though IR+ group also had higher MDA than the control group, it did not reach to a significant level (0.117+/-0.05 vs 0.101+/-0.03, p>0.05).
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Both IR- and IR+ groups had significantly higher SOD levels compared with control group (7.99+/-0.7 vs 7.28+/-0.8, p=0.009 and 8.22+/-0.8 vs 7.28+/-0.8, p=0.03, respectively).
vWF and NO levels were not different among these three groups (p>0.05).
CONCLUSIONS: Oxidative stress is prominent while endothelial dysfunction does not exist in young, non-obese patients with PCOS.
METHODS, MDA, SOD, VE and VC were measured in 30 patients with PCOS (PCOS group 1) and in 30 normal women (control group) by chemicalorimetry. After being measured, the patients with PCOS (PCOS group 1) took VE 0.1 qd x 3 months, VC 0.2 bid x 3 months and Diane-35 (Ethinylestradiol and Cyproterone Acetate Tablets) 1 # qd x 21 d/month x 3 months. The LPO, MDA, SOD, VE and VC were measured after three months. The other 30 patients with PCOS (PCOS group 2) were chosen to take Diane-35 (Ethinylestradiol and Cyproterone Acetate Tablets) 1 qd x 21 d/month x 3 months only. The menstrual cycles were viewed in PCOS group 1 and PCOS group 2 for three monthsRESULTS: The levels of maternal serum LPO and MDA in patients with PCOS (PCOS group 1) were significant higher than that in normal women (control group) (P < 0.05).
The levels of maternal serum VE, VC and SOD in patients with PCOS (PCOS group 1) were lower than that in normal women (control group) (P < 0.05).
The levels of LPO and MDA after taking Diane-35, VE and VC were lower than that before taking Diane-35, VE and VC. The levels of VE, VC and SOD after taking Diane-35, VE and VC were higher than that before taking Diane-35, VE and VC. The recoveries of menstrual cycles in PCOS group 1 were better than that in PCOS group 2.
