Psychology 261 Instructor: Ms Anne Thomas, M. A. October 5, 2000 Page 1 Imagine in your early adolescents being diagnosed with a disease that increases your aging. Doctors tell you that there is no known cure and that you will die by the age of fifty. There is a disease that increases your aging, that disease is known as Werner Syndrome. A medical student named Carl Wilhelm Otto Werner (1879-1936) first diagnosed this syndrome in 1905.
The University of Kiel invited Werner, to examine four siblings in their early late 30 s with similar symptoms. He reported that they had cataracts, premature graying, and loss of hair. Thirty years later, Oppenheimer and Kegel describe a similar case of what they termed Werner Syndrome (Harvard, pg. 1 of 1).
Werner Syndrome is an inherited disease in which patients develop symptoms post puppetry that resumes in rapid aging (Oppenheimer and Kugler 1 of 2).
(WS) is a recessive disease that had been found in DNA.
The gene for Werner Syndrome is found in the small region in chromosome 8. The genetic disease is recessive meaning that a child must inherit a defective copy from each parent to develop Werner. (Harvard 1 of 3) One in out of every 200 people may carry a single copy of the defective gene. Since the finding of Werner syndrome gene in 1995, up to 10 mutation have been reported. Most people that are diagnosed with Werner Syndrome are of Japanese decent.
Although this syndrome is more common in Japan, Werner Syndrome strikes about three in every 1 million people worldwide (SIRS Source 2 of 3).
The Essay on Werner Syndrome
... involved in the Werner syndrome phenotype, identification of the Werner syndrome gene now provides evidence that at least some components of normal aging and disease susceptibility in ... vol 337. 1997. This is a shocking picture of someone diagnosed with Werner's syndrome. It is a good picture to understand exactly what ...
Page 2 Cataracts, Osteoporosis, Heart Disease, Diabetes, and other diseases are some of the many ills that plague patients with Werner Syndrome. These diseases do not strike in the seventh or eight decade of life it strikes in the third. (SIRS Source 3 of 3).
Victims of Werner Syndrome appear to be normal during their teens, bu they began to show dramatic differences from there contemporaries in their 20 s (SIRS Source 2 of 3) Although there is no known cure for WS, recent studies show that the gene linked to Werner Syndrome has been cloned. D wane He wite states That it appears to be a DNA Helices. A DNA Helices are known to be involved in the repair and the replication and expression of genetic material (pg. 1 of 2. The cloning of the Werner Syndrome gene is important to scientist, because a cure could be found in the process of studying this gene.
Also in the future scientist can find other cures for disease, like cancers and heart disease and decrease the aging process. Some studies show that gene therapy can also contribute to slowing the process of Werner Syndrome. According to Schellenbrg The problem is that people with Werner Syndrome have so many different organs that a messed up, that means that you would have to give gene theory to the entire body, and that would be impossible to do (1 of 2).
The reason why studying Werner Syndrome is so important because scientist can get at the underlining mechanism of what causes Werner Syndrome. Schellenberg states, When you see something go wrong then youve got a handle on when things go right.
RESOURCE PAGE Hewitt, Duane Premature Aging gene Cloned. Science: 272: 199 December 10, 1996 www. lucifer@. com Lombard, D. B and Guarantee, L. (1996).
Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging. TGI 12, 283-236. Los Angeles Times (Los Angeles California) Copyright, April 12, 1996 pp. A 1+ SIRS Knowledge Source Copyright 2000 SIRS Mandarin, Inc..
