Although many affected people inherit the disorder, between 30 to 50 percent of new cases occur because of a spontaneous genetic mutation from unknown causes. Once this mutation has taken place, the mutant gene can be passed on to succeeding generations. ? Symptoms There are many symptoms for Neurofibromatosis.
These include: six or more light brown spots on the skin, often called “cafe-au-lait” spots, measuring more than 5 millimeters in diameter in children, or more than 15 millimeters across in adolescents and adults and freckling in the area of the armpit or the groin. Two or more growths on the iris of the eye, known as Lisch nodules or iris hamartomas. A tumor on the optic nerve, known as optic glioma. Abnormal development of the spine, scoliosis, the temple, sphenoid, bone of the skull, or the tibia, one of the long bones of the shin.
Many children with Neurofibromatosis have larger than normal head circumference and are shorter than average. Hydrocephalus, the abnormal buildup of fluid in the brain, is a possible complication of the disorder. Headache and epilepsy are also more likely in individuals with Neurofibromatosis than in people without it. Cardiovascular complications are associated with Neurofibromatosis, including congenital heart defects, high blood pressure, and constricted, blocked, or damaged blood vessels.
Children with Neurofibromatosis may have poor linguistic and visual-spatial skills, and perform less well on academic achievement tests, including those that measure reading, spelling, and math skills. Learning disabilities, such as attention deficit hyperactivity disorder (ADHD), are common in children with Neurofibromatosis. How is it inherited? Many affected people inherit the disorder from a parent but between 30 to 50 percent of new cases occur because of a spontaneous genetic mutation from nknown causes. Once this mutation has taken place, the mutant gene can be passed on to succeeding generations. Neurofibromatosis is due to mutation on chromosome 17 or chromosome 22. Neurofibromatosis is an Autosomal dominant disorder, In Autosomal Dominance the chance of receiving and expressing a particular gene is 50% regardless of the sex of parent or child. What is the Mutation type? Neurofibromatosis is a disorder of the nervous system that causes tumors to grow around the nerves.
Attention Deficit Disorder Attention deficit disorder is a condition characterized by the attention span that is less than expected for the age of the person. There is often age hyperactivity and impulsiveness. Attention deficit disorder is broken down in three sub categories. Attention disorder deficit / disorder: combined type, predominate inattentive and predominantly hyperactive or impulsive. ...
Tumors begin in the cells that make up the myelin sheath, a thin membrane that envelops and protects nerve fibers, and often spread into adjacent areas. The type of tumor that develops depends on its location in the body and the kind of cells involved. The most common tumors are neurofibromas, which develop in the tissue surrounding peripheral nerves. Most tumors are non-cancerous, although occasionally they become cancerous over time. Treatments There is no cure for neurofibromatosis and the goal of treatment is to relieve symptoms.
Painful cutaneous and subcutaneous tumors and those that occur on visible areas of the body may be removed surgically. Surgery also may be performed to remove schwannomas and nerve tissue tumors that cause pain, sensory loss, and loss of function. When surgery cannot be performed without risking damage to nerve function, high energy x-rays may be used to shrink tumors. ? Lifestyle changes A patient with NF can have a wide variety of lifestyle changes due to the disorder depending on the locations of the tumors.
A patient with a tumor in the nerves behind the eye could cause loss of sight while tumors in the spine can cause demobilization. People also get tumors in their brains, which can cause many mental problems. Even if the tumors do not reach crucial areas like that, the unsightly appearance of the bulges of tumors in the nerves all over the body may cause ridicule of the people around them. Extra educational services Since there is a higher than average risk for learning disabilities, children with NF1 should undergo a detailed neurological exam before they enter school.
Illegal Drugs: Their effects on the body There are many types of drugs, and they have many different effects on the body. Drugs can kill those abuse them in 3 different ways: by overdose, through side effects or bad reactions, and as a means of committing suicide. Some drugs may cause both murderous and suicidal behavior. The hallucinogens, especially PCP, are infamous in this respect. Valium has ...